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이구연 교수

이구연 교수님
이구연 교수
  • 연구분야 : 천연물합성, 의약합성, 유기합성법 개발
  • 전화번호 : 직장 033)250-6477
  • E -mail : lky@kangwon.ac.kr
학력
  • 1999 강원대학교 화학과 이학사
  • 2001 강원대학교 화학과 이학석사
  • 2004 강원대학교 화학과 이학박사
주요경력
  • The Scripps Research Institute, Post-Doc
  • ㈜유한양행 중앙연구소, 책임연구원
연구분야
  • 천연물 합성
  • 의약 합성
  • 유기합성법 개발
연구실적
1) 학위논문
  • 박사학위: I. Pd-catalyzed cross-coupling reaction using indium reagents II. Indium-mediated 1,4-addition onto α,β-unsaturated ketone: Reactions of sulfonium salt with organoindium reagents
  • 석사학위: Studies on the novel organic synthesis using indium reagents
2) 정기학술지
  • 1. Iron-catalyzed indirect hydration of alkynes in presence of methanesulfonic acid
    Tetrahedron Lett. 2013, 54, 4414-4417.
  • 2. Brønsted Acid Catalyzed Intramolecular Hydroarylation for the Synthesis of
    Cycloalkenyl Selenides and Tellurides
    Eur. J. Org. Chem. 2013, 13, 2672-2682.
  • 3. Enhanced oral bioavailability and antiasthmatic efficacy of curcumin using redispersible dry emulsion
    Bio-Medical Materials and Engineering 2013, in press
  • 4. Improved bioavailability and antiasthmatic efficacy of poorly soluble curcumin-solid dispersion granules
    obtained using fluid bed granulation Bio-Medical Materials and Engineering 2013, in press
  • 5. Inhibitory effects of Capsicum annuum L. water extracts on lipoprotein lipase activity in 3T3-L1 cells
    Nutr Res Pract 2013, 7, 96-102.
  • 6. Molecular identification based on the nuclear ribosomal DNA (nrDNA ITS) region in genus Alstroemeria
    J. Med. Plans Res. 2013, ISBEN04, 344-348.
  • 7. Palladium-catalyzed allyl cross-coupling reactions with in situ generated organoindium reagents
    Chem. Asian J. 2011, 6, 2147-2157.
  • 8. Efficient Synthetic Method of Multisubstituted Allenes from the Reactions of Allylindium Reagents with 3o-Propargyl Alcohols
    Org. Lett. 2008, 10, 2441-2444.
  • 9. Efficient Homo-Coupling Reactions of Heterocyclic Aromatic Bromides Catalyzed by Pd(OAc)2 Using Indium
    Tetrahedron Lett. 2008, 49, 4302-4305.
  • 10. Synthesis of Cyclic Compounds Having exo-Methylene Group through the Diels-Alder Reaction of Vinyl Allenes Obtained from Propargyl Bromides and Indium
    Bull. Korean Chem. Soc. 2008, 29, 487
  • 11. Indium-Mediated Selective Introduction of a 1,3- Butadienyl-2-yl Group at the C4-Position in 2- Azetidinones and Application of 1,3-Diene-Thered 2-Azetidinones and the Diels-Alder Reaction
    Chem. Eur. J. 2007, 13, 8877-8883
  • 12. Gold-Catalyzed 5- and 6-exo-dig Selective Cyclizations of Alkynyl Silyl Enol Ethers: Efficient Method for [3+2] and [4+2] Annulation onto-Enones
    Adv. Synth. Catal. 2007, 349, 2092-2096
  • 13. Inter- and intramolecular palladium-catalyzed allyl cross-coupling reactions using in situ generated allylindium from allyl acetates with indium trichloride
    Chem. Eur. J. 2007, 13, 5197-5206
  • 14. In situ generation of vinyl allenes and its applications to one-pot assembly of cyclohexene, cyclooctadiene, 3,7-nonadienone, and bicyclo[6.4.0]dodecene derivatives with Pd-catalyzed multicomponent reactions
    J. Am. Chem. Soc. 2006, 128, 1139-1146
  • 15. Intermolecular tandem Pd-catalyzed cross-coupling/ [4+4] and [4+2] cycloadditions: A one-pot, five- component assembly of bicyclo[6.4.0]dodecanes
    Angew. Chem. Int. Ed. 2005, 44, 3253-3256
  • 16. The indium-mediated selective introduction of allenyl and propargyl groups at the C4-position of 2- azetidinones and the AuCl3-catalyzed cyclization of 4-allenyl-2-azetidinones
    Angew. Chem. Int. Ed. 2005, 44, 1840-1843
  • 17. Indium-mediated β-allylation, β-propargylation, and β- allenylation onto α,β-unsaturated ketones: Reactions of in-situ-generated 3-tert-butyldimethylsilyloxyalk-2-en-ylsulfonium salts with in-situ-generated organoindium reagents
    J. Am. Chem. Soc. 2003, 125, 9682-9688
  • 18. Highly efficient catalytic synthesis of substituted allenes using indium
    Angew. Chem. Int. Ed. 2002, 41, 3901-3903
3) 지적재산권
  • 1. 불포화 알데히드 화합물의 제조방법 (METHOD OF PREPARING UNSATURATED ALDEHYDE COMPOUND)
    출원번호: 10-2013-0010345
  • 2. 케톤계 화합물의 제조방법 (METHOD OF PREPARING KETONE COMPOUND)
    출원번호: 10-2013-0010298
  • 3. 알케닐 트리플레이트 유도체의 제조방법 (Method of preparing alkenyltriflate derivatives)
    출원번호: 10-2012-0052782
  • 4. 신규한 헤테로고리 화합물 유도체 및 철촉매를 이용한 이의 제조방법 (Novel heterocyclic compound
    derivatives catalyzed by iron and its preparation method)
    등록번호: 10-1220154
  • 5. 신규한 고리형 바이닐 포스페이트 유도체와 이의 제조방법 (Novel cyclic vinyl phosphate derivatives
    and its preparation method)
    등록번호: 10-1170687
  • 6. 신규의 글루코키나제 활성화제 및 그의 제조방법 (NOVEL GLUCOKINASE ACTIVATORS AND PROCESSES FOR THE PREPARATION THEREOF)
    출원번호: 10-2010-0091621
  • 7. 유기 인듐을 이용하여 불포화 탄화수소 화합물 분자내 탄소들간의 결합방법 (Coupling method between carbons in the unsaturated hydrocarbon compound using organo-indium compound as coupling agent)
    출원번호: 10-2006-0130535
  • 8. 알렌 치환된 불포화 화합물 및 이의 제조방법 (Allene substituted unsaturated compounds and synthesis of them using indium)
    출원번호: 10-2007-0101076
위로
24341 강원도 춘천시 강원대학길1 의생명과학대학 Tel : 033)250-7601-2 FAX : 033)259-5640
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