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이해익 교수

이해익 교수님
이해익 교수
  • 전공 : 효소공학
  • 전화번호 : 직장 033) 250 - 6481
  • E -mail : rheehae@kangwon.ac.kr
  • 연구실 : 의생명과학관 A-214 (효소공학 실험실 : B-218호)
학력
  • 학사 : 강원대학교 농화학과
  • 석사 : 강원대학교 농화학과
  • 박사 : 쿄오토대학 대학원 식품공학과(미생물 생화학)
주요경력
  • 생물응용공학과장 1990.03 - 1991.02
  • 생물응용공학과장 1991.03 - 1992.02
  • USDA/ARS Research Chemist 1992.06 - 1993.06
  • 생물응용공학과장 1994.03 - 1995.02
  • 생물응용공학과장 1995.03 - 1996.02
  • 농업생명과학대부학장 1998.02 - 2000.02
  • 식품생명공학부장 2000.03 - 2001.02
  • 농업과학연구소장 2003.03 - 2005.02
  • 총장임명추천위원회 2004.04 - . 위원
  • 평의원회 2004.05 - 2005.03 위원
  • 농업생명과학대학장 직무대리 2005.03 - 2005.03
  • 농장장 직무대리 2005.03 - 2005.03
  • 교육공무원공적심사위원회 2005.03 - 2007.03 위원
  • 농업생명과학대학장 2005.03 - 2006.02
  • 농장장 2005.03 - 2006.02
  • 강원도농업기술원 2006.07 - 2008.06 겸임연구관
연구분야
  • 효소공학, 미생물 생산, 효소저해 개발
연구실적
1) 학위논문
  • 박사학위논문 Enzymatic and Genetic Studies on the metabolism of 2- oxoaldehydes in Pseudomonades. 쿄오토대학 1988

2) 정기학술지
  • Antioxidative effect of purple corn extracts during storage of mayonnaise, Food Chemistry 2014
  • Physicochemical Properties of Low-Phytate Rice Cultivar, Sang-gol, J. Korean Soc. Appl. Biol. Chem. 2012
  • Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in rats, Alcohol, 2008
  • Corn Husk as a Potential Source of Anthocyanins, J. Agric. Food Chem., 2008
  • Immunological characterization of honey major protein and its application, Food Chemistry, 2009
  • Honey major protein characterization and its application to adulteration detection, Food Research International, 2008
  • 압출성형에 의한 ginsenoside의 변환, J. Korean Soc. Appl. Biol. Chem., 2008
  • 회향열수 추출물의 치면 세균막 형성 억제 효과, J. Korean Soc. Appl. Biol. Chem., 2008
  • A new medium-late maturing rice cultivar with low phytate content "Sanggolbyeo", Korean J. Breed. Sci., 2007
  • 고추의 α-glucosidase 저해제 고활성 계통 선발 및 특성평가, 한국생물환경조절학회지, 2007
  • 돌연변이체로부터 α-glucosidase 저해활성이 높은 계통의 선발, 한국육종학회지, 2007
  • Food chemical properties of low-phytate rice cultivar, Sang-gol, Journal of Cereal Science, 2008
  • An efficient inhibitor of glucosyltransferase, FEBS Letters, 2007
  • A lipase inhibitor from the roots of Glycyrrhiza uralensis, Food Research International, 40 (2007)
  • 발광미생물을 이용한 수질오염 감시 시스템 개발, 산학협동연구, 2006
  • Free radical scavenging and hepatoprotective actions of Quercus aliena acorn extract against CCl₄-induced liver, Free Radical Research, 2005
  • Inhibitory effect of pine extract on alpha glucosidase activity and postgrandial hyperglycemia, Nutrition, 2005
  • Overexpression of Arabidopsis ACK1 alters leaf morphology and retards growth and development, Biochemical and Biophysical Research Communications, 2005
  • Hepatoprotective and antioxidant effects of Morus bombycis Koidzumi on CCl₄-induced liver damage, Biochemical and Biophysical Research Communications, 2005
  • Studies on the inhibitory effect of Eugenia aromaticum extract on pancreatic lipase, Journal of Korean Society for Applied Biological Chemistry, 2005
  • 말채나무추출물의 알파-amylase 저해활성, 한국응용생명화학회지, 2005
  • Biosorption of Hexavalent Chromium by Pachymeniopsis sp. Dead Cells, Agricultural Chemistry and Biotechnology,
  • A novel α-glucosidase inhibitor from pine bark, Carbohydrate Research, 2004
  • 해조류로부터 6가 크롬 흡착 저해제의 선발, 강원대학교 농업과학연구소 논문집, 2003
  • Molecular cloning and expression of cDNA encoding cytosolic ascorbate peroxidase from Pimpinella brachycarpa, Journal of Plant Physiology,
  • Removal of chromate by white rot fungus, Inonotus cuticularis, Journal of Microbiology and Biotechnology, 2002
  • 남북한 농업기술 협력사업의 현황과 과제, 산업과 경제, 2001
  • Genetic modification in the cyclin gene from a Nicotiana interspecific hybrid: Role of the GTcyc gene in tumorization process, Journal of Plant Physiology, 2001
  • Improved Technique for Isolating RNA from Tobacco Tissues, Plant Molecular Biology Reporter, 2001
  • Amino acid substitution within the S2 and S4 transmembrane segments in shaker potassium channel modulates channel gating, Biochemical and Biophysical Research Communications, 2000
  • Screening of hexavalent chromium biosorbent from marine algae, Applied Microbiology and Biotechnology, 2000
  • Identification and expression of the GTcyc cDNA clone from genetic tumors formed on Nicotiana glauca-N. langsdrffii hybrid, Plant Physiology and Biochemistry, 2000
  • Effects of NPK fertilizers on antioxidant activity of corn(Zea mays L.) 한국토양비료학회지, 2000
  • Isolation of peptide ligands that inhibit glutamate recemase activity from a random phage display library, Journal of Biomolecular Screening, 2000
  • Properties of anionic peroxidases purified from Chinese cabbage roots, Plant Physiology and Biochemistry,
  • Isolation of rice allergenic cDNA clones from a rice cDNA library by immunoscreening with a polyclonal antibody specific to 16kD rice allergenic protein, Experimental and Molecular Medicine, 1999
  • 찰옥수수 F1의 지방산 조성과 항산화 활성, 한국식품과학회지, 1999
  • 동물세포 배양액으로부터 암모늄 이온의 동시제거를 위한 고정화 흡착제의 개발과 동물세포 배양 시스템에의 응용 : II. 세포 배양 시스템에의 응용, 한국생물공학회지, 1998
  • 단백질 전기영동을 이용한 토종꿀의 판별, 한국식품과학회지, 1998
  • Purification of peroxidase from Chinese Cabbage Roots by the reverse micell system, Journal of Microbiology and Biotechnology, 1998
  • 옥수수 종실의 지방산과 스테롤의 조성 및 불검화물의 함량, 식량작물연구논문집, 1998
  • Contents of phytic acid and minerals of rice cultivars from Korea, 한국식품영양과학회지, 1997
  • Effects of dietary phytic acid on the lipid and mineral profiles in rats, Food Science and Biotechnology, 1997
  • 강원도산 토종꿀의 식품학적 특성, 한국식품과학회지, 1997
  • Ammonium ion effects and its in situ removal by Using immobilized adsorbent in hybridoma cell culture, 한국생물공학회지, 1996
  • Variation of several agronomic and biochemical traits in γ-ray induced mutant soybeans, 한국육종학회지, 1996
  • 대두미분해성단백질로부터 chemiluminescence법에 의한 담즙산 결합 peptide의 탐색, 한국영양식량학회지, 1996
  • 배추뿌리의 Peroxidase를 이용한 Phenol의 제거, 한국생물공학회지, 1995
  • 닭에 있어서 찔레 뿌리 추출물의 혈청 콜레스테롤 강하작용에 관한 연구, 대한지질학회지, 1993
  • Comparative effects of dietary Palm oil, perilla oil, and soybean oil on lipid profiles in differently aged rats fed on hypercholesterolemic diets, Bioscience Biotechnology and Biochemistry, 1993
  • 메밀의 영양성분과 냉동건조 막국수의 이화학적 성질, 한국영양식량학회지, 1991
  • One-step purification of Cholesterol oxidase from Pseudomonas sp. culture broth using a novel affinity chomatography method, J. Gen. Microb. Microbiol. 1991
  • Influence of extract of Rosa rugosa roots on lipid levels in serum and liver of rats, Life Sciences, 1991
  • Phospholipase D 에 의한 비천연 인지방질의 합성;Ⅱ. 포스파티딜기 전이반응에 미치는유기용매의 효과, 한국생물공학회지, 1991
  • Nicotiana sp. 진탕배양세포를 이용한 Nicotine 생성조건, 과학기술연구, 1991
  • Phospholipase D에 의한 비연천연인지방질의 합성;Ⅰ.에멀젼계내에서의 합성, 한국생물공학회지, 1991
  • 배추기원 Peroxidase의 정제 및 성질, 한국산업미생물학회지, 1991
  • Purification of Cholesterol esterase from Aeromonas sp., 한국생물공학회지, 1990
  • Enzymatic and genetic aspects of glyoxalase I in microorganisms, Kor. J. Appl. Microbiol. Bioeng. 1990
  • 다중교반형 생물반응기에 의한 Phospholipase D의 특성 연구, 한국생물공학회지, 1990
  • Some aspects of 2-oxoaldehydes metabolism in microoraganisms, Canadian Journal of Microbiology, 1989
  • Purification and characterization of cholesterol oxidase from Pseudomonas sp. and taxonomic study of the strain, Applied Microbiology and Biotechnology, 1989
  • Nucleotide Sequence of the Glyoxalase I Gene of Pseudomonas putida, Agric. Biol. Chem., 1988
  • Glyoxalase I and its application to production of S-lactoylglutathione, Enzyme, Nucleic acid and Protein , 1988
  • Production of S-lactoylglutathione by glycerol-adapted Saccharomyces cerevisiae and genetically engineered Escherichia coli cells, Applied Microbiology and Biotechnology, 1988
  • L-Alanine:4,5-Dioxovalerate Aminotransferase from Pseudomonas riboflavina: Purification and Inactiviation by Methylglyoxal, Journal of Biochemistry, 1988
  • Metabolism of 2-oxoaldehyde in mold: Purification and characterizat ion of two methylglyoxal reductases from Aspergillus niger, European Journal of Biochemistry, 1988
  • Molecular Cloning of the Pseudomonas putida Glyoxalase I Gene in Escherichia coli, Biochemical and Biophysical Research Communications, 1987
  • Formation of the Herbicide δ-Aminolevulinate, from L-Alanine and 4,5- Dioxovalerate by Pseudomonas riboflavina, Agric. Biol. Chem., 1987
  • Metabolism of 2-Ketoaldehydes in Bacteria: Oxidative Conversion of Methylglyoxal to Pyruvate by an Enzyme from Pseudomonas putida, Agric. Biol. Chem., 1987
  • Metabolism of 2-oxoaldehydes in mold: Characterization of glyoxalase I from Aspergillus niger, Journal of Biochemistry, 1987
  • Purification and Characterization of Glutathione Thiol Esterase from Saccharomyces cerevisiae, Agric. Biol. Chem., 1987
  • Metabolism of 2-Ketoaldehydes in Mold: Purification and Characterization of Glyoxalase I from Aspergillus niger, Journal of Biochemistry, 1987
  • Purification and Characterization of Glyoxalase I from Pseudomonas putida, Biochemical and Biophysical Research Communications, 1986
  • Analysis of Phospho- and Phosphonosphingolipids by High-Performance Liquid Chromatography, Journal of Biochemistry, 1984
  • A study on the lipid components in sporangiophores of Phycomyces sp., 한국식품과학회지, 1979
  • 감자塊莖 및 감자 澱粉中의 無機質에 關한 硏究 강원대학교 논문집 1978
  • 감자 澱粉의 理化學的 性質에 關한 硏究 강원대학교 연구논문집 1977

3) 단행본
  • Oleic Acid and Inhibition of Glucosyltransferase. In: Victor R. Preedy and Ronald Ross Watson, editors, Olives and Olive Oil in Health and Disease Prevention. Oxford: Academic Press, 2010, pp. 1375-1383. ISBN: 978-0-12-374420-3
  • 저서 생명공학개론 강원대학교 출판부 2003
  • 저서 식품과 생명 강원대학교 출판부 2000
  • 편저 Production of microbial enzymes by genetic engineering and its application: High Technology Information for Specialist Aizawa K.CMC Press 1988

4) 연구보고서
  • 식물 추출물로부터 Iipase저해제의 탐색 2005
  • 분자생물학적 기법을 이용한 토종 및 양봉꿀의 판결법 개발 2004
  • 토양개량용 바이오 액상비료 생산기술개발 2003
  • 남북한 농업기술협력사업의 현황과 과제 2001
  • 배추뿌리로부터 유용효소의 생산 1999
  • 강원대학교의 남북농업협력에 관한 연구 1998
  • LOW Phytate Rice의 생화학적 특성(연수자 : 이득식) 1997
  • Pachymeniopsis sp.를 이용한 Cr+6 제거 system의 개발 1997
  • 토종꿀 진품판별법 개발에 관한 연구용역 1996
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