김세호 교수
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김세호 교수

김세호 교수님
김세호 교수님
  • 전공 : 분자면역학/항체공학
  • 연구분야 : 항체공학/항체치료제 개발/바이오의약품 개발
  • 연락처 : 033-250-7364
  • 이메일 : kimsho@kangwon.ac.kr
학력
  • 1983 서울대학교 학사 (농화학)
  • 1990 건국대학교 석사 (면역화학)
  • 1998 Weizmann Institute of Science 박사 (면역학)
주요경력
  • 2013. 9 ~ 현재 강원대학교 산학협력단/시스템면역과학과
  • 2014. 10 - 2015. 2 강원대학교 산학협력단 R&D 전략부장
  • 2015. 1 ~ 현재 강원대학교 산학협력단 연구지원과장
  • 1983. 7 ~ 2013. 7 ㈜녹십자 종합연구소 (연구원, 선임, 책임, 수석, 이사, 상무)
  • 1997. 5 ~ 1999. 6
    Postdoctoral research fellow. Antibody engineering lab., Massachusetts General Hospital/Harvard Medical School, Boston.
학위논문
  • 박사학위논문 : A genetic approach to elucidate the mechanism of antibody-mediated catalysis using esterolytic antibodies as a model system
  • 석사학위논문 : Development of chemiluminescence immunoassay of human ∂-fetoprotein and its epitope mapping using monoclonal antibodies.
연구실적 (논문 및 특허실적)
논문
  • Chung YS, Son JK, Choi B, Joo SY, Lee YS, Park JB, Moon H, Kim TJ, Kim SH, Hong S, Chang J, Kang MS, Kim SJ (2015) Co-transplantation of human fetal thymus, bone and CD34+ cells into young adult immunodeficient NOD/SCID IL2Rγnull mice optimizes humanized mice that mount adaptive antibody responses. Clin Immunol. 157: 156-165
  • Cho KJ, Hong KW, Kim SH, Seok JH, Kim S, Lee JH, Saelens X, Kim KH (2014) Insight into highly conserved h1 subtype-specific epitopes in influenza virus hemagglutinin. PLoS One. 9(2): 1-9
  • Shin TH, Sung ES, Kim YJ, Kim KS, Kim SH, Kim SK, Lee YD, Kim YS (2014) Enhancement of the tumor penetration of monoclonal antibody by fusion of a neuropilin-targeting peptide improves the anti-tumor efficacy. Mol Cancer Ther. 13(3):1-11
  • Park GC, Hwang S, Ahn CS, Kim KH, Moon DB, Ha TY, Song GW, Jung DH, Shin YW, Kim SH, Chang KH, Namgoong JM, Park CS, Park HW, Park YH, Kang SH, Jung BH, Lee SG (2013) Analysis of S gene mutation of the hepatitis B virus in adult liver transplant recipients showing resistance to hepatitis B immunoglobulin therapy. Transplant Proc. 45(8):3047-511
  • Cho KJ, Lee JH, Hong KW, Kim SH, Park Y, Lee JY, Kang S, Kim S, Yang JH, Kim EK, Seok JH, Unzai S, Park SY, Saelens X, Kim CJ, Lee JY, Kang C, Oh HB, Chung MS, Kim KH (2013) Insight into structural diversity of influenza virus hemagglutinin. J Gen Virol.
  • Chang KH, Kim MS, Hong GW, seo MS, Shin YN, Kim SH (2012) Affinity Maturation of an Epidermal Growth Factor Receptor Targeting Human Monoclonal Antibody ER414 by CDR Mutation. Immune Network 12(4):155-64
  • Chang KH, Kim MS, Hong GW, Shin YN, Kim SH (2012) Conversion of an EGFR targeting murine monoclonal antibody A13 to a human monoclonal antibody by guided selection. Experimental & Molecular Medicine 44 (1):52-59.
  • Hong KW, Kim CG, Lee SH, Chang KH, Shin YW, Ryoo KH, Kim SH*, Kim YS. (2010) A novel anti-EGFR monoclonal antibody inhibiting tumor cell growth by recognizing different epitopes from cetuximab. J Biotechnol. 145(1):84-91.
  • Kim SH*, Shin YW, Hong KW, Chang KH, Ryoo KH, Paik SH, Kim JM, Brotman B, Pfahler W, Prince AM (2008) Neutralization of hepatitis B virus (HBV) by human monoclonal antibody against HBV surface antigen (HBsAg) in chimpanzees. Antiviral Res. 79(3):188-91
  • Kim SH*, Oh HK, Ryu CJ, Park SY, Hong HJ (2008) In vivo hepatitis B virus-neutralizing activity of an anti-HBsAg humanized antibody in chimpanzees. Experimental and Molecular Medicine 40(1): 145-149.
  • Shin YW, Ryoo KH, Hong KW, Chang KH, Choi JS, So M, Kim PK, Park JY, Bong KT, Kim SH*. (2007) Human monoclonal antibody against hepatitis B virus surface antigen (HBsAg). Antiviral Res. 75(2):113-20.
  • Hong HJ, Ryu CJ, Hur H, Kim SH, Oh HK, Oh MS, Park SY. (2004) In vivo neutralization of hepatitis B virus infection by an anti-preS1 humanized antibody in chimpanzees. Virology 318(1):134-141.
  • Kim SH*. (2003) Expression and purification of recombinant immunotoxin - a fusion protein stabilizes a single-chain Fv (scFv) in denaturing condition. Protein Expr Purif. 27(1):85-89.
  • Kim SH* and Park SY (2002) Selection and characterization of human antibodies against hepatitis B virus surface antigen (HBsAg) by phage-display. Hybridoma and Hybridomics 21 (5):385-392.
  • Lindner AB, Kim SH, Schindler DG, Eshhar Z, Tawfik DS. (2002) Esterolytic antibodies as mechanistic and structural models of hydrolases-a quantitative analysis. J Mol Biol. 320(3):559-572.
  • Kim SH*, Chun JH, Park SY. (2001) Characterization of monoclonal antibodies against carcinoembryonic antigen (CEA) and expression in E. coli. Hybridoma 20 (4): 265-272.
  • Kim SH*, Song SH, Kim YJ, Park SY. (2001) Expression and characterization of a recombinant Fab fragment derived from an anti-human alpha-fetoprotein (AFP) monoclonal antibody. Mol & Cells 11 (2): 158-163.
  • Kim SH*. (2001) Development of a one-step two-site enzyme immunoassay for measuring human alpha-fetoprotein by eliminating hook-effect. J. Biochem. & Mol. Biol. 34 (1): 47-50.
  • Yun JW, Lee SY, Choi BW, Oh HK, Kim SH, Byun TH, Park SY. (2000) Continuous stable production of von Willebrand Factor monoclonal antibody in spin filter bioreactor with bleeding technology. Biotechnol. Bioprocess Eng 5 (2): 130-135
  • Kim SH, Titlow CC, Margolies MN. (2000) An approach for preventing recombination-deletion of the 40-50 anti-digoxin antibody V(H) gene from the phage display vector pComb3. Gene 241 (1):19-25.
  • Kim SH, Schindler DG, Lindner AB, Tawfik DS, Eshhar Z. (1997) Expression and characterization of recombinant single-chain Fv and Fv fragments derived from a set of catalytic antibodies. Mol Immunol 34 (12-13):891-906.
  • Charbonnier JB, Golinelli-Pimpaneau B, Gigant B, Tawfik DS, Chap R, Schindler DG, Kim SH, Green BS, Eshhar Z, Knossow M. (1997) Structural convergence in the active sites of a family of catalytic antibodies. Science 275 (5303):1140-1142.
  • Tawfik DS, Lindner AB, Chap R, Kim SH, Green BS, Eshhar Z. (1997) CatELISA: ELISA-based detection of catalytic antibodies and enzymes. Immunology Methods Manual (edited by Ivan Lefkovits). Section 8.8, p553-560. Academic Press, London.
  • Kim SH, Kim CK, Kwon OJ, Chung KS, Kim JB. (1990) Development of immunochemiluminometric assay (ICMA) for the measurement ?-fetoprotein (AFP) and mapping of the antigenic epitopes of AFP. Bioluminescence and Chemiluminescence-Current Status (edited by Philip E. Stanley & Larry J. Kricka). P199-202. John Wiley & Sons.
  • Kim SR, Suh PG, Juhnn YS, Kim SH, Chung HK, Kimm SW. (1988) Purification of ?-fetoprotein from cord serum by monoclonal immunoaffinity chromatography. Korean J. of Biochem. 20 (2), 93-98.
  • 김세호 (2011) 바이오시밀러 정의 및 타깃. 과학과 기술 (The Science & Technology). Vol.506, 14-18.
  • 김세호 (2002) 치료항체공학 (Therapeutic antibody engineering). Bioindustry 31 (한국생물산업협회). P36-41.
  • Kim SH*, Oh HK, Jung SM, Byun TH, Hong HJ, Park SY (1999) Development of therapeutic humanized antibodies against surface antigens of hepatitis B virus. A symposium on the recent trend of development of therapeutics against liver diseases, p8-10, 덕성여대 약학 심포지움.
특허 출원
번호 특허명 등록/출원번호 둥록/출원일 비고
1 B형 간염 바이러스의 표면 항원에 대한 인간항체 (Human antibodies against the surface antigen of HBV), 등록번호: 0467706 2005.1.13 국내등록
2 항-암종태아항원 단일클론 항체 및 그로부터 제조되는 단일쇄 Fv (anti-carcinoembryonic antigen monoclonal antibody and single chain fv prepared therefrom), 등록번호:0473713 2005. 2.18 국내등록
3 B형 간염 바이러스의 표면항원에 대한 인간항체의 가변 영역을 삽입할 수 있는 항체발현 플라스미드, (Plasmid to be inserted with variable region of human antibodies against the surface antigen of HBV) 등록번호: 0523732 2005.10.18 국내등록
4 ScFv 형태의 항체 라이브러리를 제작하기 위한 항체 ScFv 발현 벡터 (vector DNA expressing scFv for producing scFv antibody library), 등록번호: 0635370 2006.10.11 국내등록
5 항파상풍 단일클론 항체 및 이를 생산하는 하이브리도마 세포주(monoclonal antibodies having neutralizing activity against tetanus toxoid and hybridoma cell lines producing the same), 등록번호: 0624011 2006.9.7 국내등록
6 항-EGF 수용체 단일클론항체 및 이를 생산하는 하이브리도마 세포주 (monoclonal antibody against epidermal growth factor receptor and hybridoma cell line producing the same), 등록번호: 0680141 2007.2.1 국내등록
7 항-B 림프종 단일클론 항체 및 이를 생산하는 하이브리도마 세포주 (monoclonal antibody against B-lymphoma and hybridoma cell line producing the same), 등록번호: 0701923 2007.3.26 국내등록
8 표피 성장 인자 수용체에 특이적으로 결합하는 항체(Antibodies specifically binding to the epidermal growth factor receptor) 등록번호 1108642 2012.1.16 국내등록
PCT/KR2009/
006380
2009.11.2 PCT 출원
9 B형 간염 바이러스 표면항원에 특이적으로 결합하는 인간항체{HUMAN ANTIBODIES SPECIFICALLY BINDING TO THE HEPATITIS B VIRUS SURFACE ANTIGEN} 등록번호 1072895 2011.10.6 국내등록
PCT/KR2010/
004445
2010. 7.8 PCT 출원
10 B형 간염 바이러스 표면 항원상의 에피토프 및 이의 용도 Epitope and its use of Hepatitis B virus surface antigen 출원번호 10-2011-0064671 2011. 6. 30 국내출원
PCT/KR2011/
005477
2011.7.25 PCT 출원
11 Three dimensional structure of EGF receptor and its epitope U.S. Provisional Application 61/616,073 2012.3.27 미국출원
12 표피 성장 인자 수용체 표면 항원상의 에피토프 및 이의 용도; PCT/KR2013/
002550
2013.3.27 PCT 출원
13 B형 간염 돌연변이 바이러스 감염의 예방 또는 치료용 항체 조성물{An antibody composition for prevention or treatment of mutant hepatitis B virus infection} 출원번호 10-2012-0075063 2012.7.10 국내출원
PCT/KR2013/
006025
2013.7.8 PCT 출원
위로
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