Structural Biology Laboratory
- Biomedical Science building, Room A-201, A-209
- Sung-il Yoon, Ph.D.
Our research aim is to determine 3-dimensional structures of biologically significant macromolecules at the atomic resolution using X-ray crystallography and to define their biological functions through structure-based biophysicochemical studies. We are particularly interested in revealing structural and molecular mechanisms for immune responses against pathogens as well as pathogenesis of infectious diseases.
Major research areas
Structural and mechanistic studies on pathogen recognition by immune receptors
- Toll-like receptor 5 (TLR5) activation by bacterial flagellin
- Drug development of flagellin variants
Structural basis of antigen recognition by therapeutic antibodies
Structural studies on microbial pathogenesis focusing on virulence factors
Structure-function studies on bacterial transcription factors and enzymes
- Enzymatic mechanism of methyltransferase, nucleotide hydrolase, and glycosyl transferase
- Gene regulation by transcription factors